Employing a personalized strategy by taking into account the patient‟s specific conditions, Integrative Medicine (IM) endeavours to apply all appropriate interventions from a whole set of science branches to bring back health. However, this does not remain fully without its own challenges from almost all sides. Complementary and Alternative Medicine (CAM) on the one hand, and: Evidence Based Medicine (EBM), on the other, have their own rightful say in the affair. In order to be able to check up and down on the modalities of research as far as unforeseen challenges into the future are concerned (let alone those already extant), we have devised some a priori vs a posteriori systematology whereby experimental subjects are [constantly] "re-shuffled": then, groupings of instantiations are posed one onto the other so that a certain RCT could approximately represent (without necessarily presenting) another run of a similar RCT.