Interleukin-22 (IL-22) structurally belongs to the IL-10 family of cytokines, which is expressed by Th22 cells and natural killer (NK) cells, lymphoid tissue inducer (LTi) cells, LTi-like cells and some other cells.Recently, the role of IL22 in creating the protection and natural defense mechanism for controlling bacterial infections, viral hemostasis and tissue recovery has been proved. IL-22 plays a protective role in wound healing of tissues such as skin. IL-22 acts byheterodimeric receptors and consists of IL-22R1 and IL-10R2. Human skin has the highest IL-22R1 expression among other tissues. The effect of IL-22 on skin tissue is related to the level of this cytokine and, in a limited range, has extraordinary wound healing effect and out of this range IL-22 may also have contradictory results. IL22 provokes the expression of molecules such as keratin 6, which provokes hyperplasia of reconstituted human epidermis. In addition, keratinocyte migration is increased by IL-22 stimulation.IL-22 plays a protective role in wound healing of tissues such as intestine and liver. IL-22- deficient mice showed delayed healing of mucosal wound healing compared to controls.IL-22 enhances the expression of βdefensin2 and-defensin3, which might be related to the increased innate immunity against pathogens.IL-22 in various skin damages. IL-22 is expressed after burn wounding, is elevated in human psoriasis patients, and promotes dermal inflammation.