Abstract

Abstract : The main objective of study is to design and evaluate the propranolol hydrochloride sustained release bilayer tablet for reduce frequency of administration and increase the efficacy and oral bioavailability of the drug. Propranolol hydrochloride is a nonselective beta adrenergic blocking agent; it is used in the treatment of hypertension, angina pectoris and many other cardiovascular disorders. The tablets were prepared by direct compression method by using superdisintegrants Kyron T-314 for immediate release mucoadhesive materials such as Hydroxy propyl methyl cellulose (HPMC-K4M) and ethyl cellulose for sustained release layer which could release the drug up to 12 hours in predetermined rate. Starch paste was used as binder. The formulation F4 containing HPMC-K4M and Ethyl cellulose both polymers used in combination they show a higher rate of drug release up to 12 hours. Propranolol hydrochloride using superdisintegrants Kyron T-314 for fast release layer and combination of HPMC K4M and Ethyl cellulose for sustaining release layer. The tablets showed an initial burst release to provide up to 12 hours of loading dose of the medication accompanied by a sustained release. This modified release bilayer tablets also reduced dosing frequency, increase the bioavailability and provide better patient compliance.