Synthesis and Biological Evaluation of Novel Coumarin Derivatives for its Antidiabetic Activity

Pallavi K. Vawhal, Dr. Shailaja B. Jadhav 1

8th WCPSDM.2021. APR.Published Online 18 APR 2021

Abstract : Coumarin belongs to a group as benzopyrones, which consists of a benzene ring joined to a pyrone nucleus. Coumarins is well-known for its various biological activities like anticoagulant, antimicrobial, anti-inflammatory, analgesic, antioxidant, anticancer, antiviral, antimalarial activity. The rationale of the present study is incorporation of another heterocyclic moiety, either as a substituent or a fused component into coumarin, alters the properties of the parent material and the resulting compounds generally exhibit promising or unprecedented properties. Sixteen new coumarin derivatives were synthesized and characterized by IR and 1H NMR spectra. These newly formed Coumarin derivatives were screened for antidiabetic activity by in vivo and in vitro study using DPPH-4 enzyme assay. The results of present investigation showed that the compounds significantly shown activity for reducing blood sugar level without sugar degeneration.