Development and Characterization of Natural Polymers Based Gastroretentive Tablets for the Effective Management of Diabetes

Subhash Sharma, Navneet Garud 1

8th WCPSDM.2021. APR.Published Online 18 APR 2021

Abstract : The mucoadhesive tablets of metformin hydrochloride was prepared by using the polymers of different grades namely Hydroxy Propyl Methyl Cellulose K100M xanthan gum , tamarind gum, Starch, magnesium sterate ,carbapol ,and Sodium bicrobonate in different concentrations were prepared separately by direct compression method.
The formulations were evaluated for various physical parameters, Hardness3.5±0.1, friability 0.51±0.1, thickness 5.18±0.12Drug content98.48 ±0.78, Average weight 750.18±0.68 dissolutionparameters and drug released mechanisms.Among all the formulations,F6 containing drug prepared with tamarind gum showedpromising result releasing94.49%of drug in 12 hrs with a lag, time of 56 seconds and duration of bioadhesive time is 12hrs the mechanism of drug release from tablet was observed to zero order kinetics . with improved patient compliance.