Abstract

Abstract : Background: Anticoagulants commonly known as blood thinners they are chemical substances that prevent coagulation of blood, by prolonging clotting time. Drug utilization an evaluation of anticoagulant drugs essential considering it as narrow therapeutic range and associated risks.Aim: To study DUE of anticoagulants and emphasizing on ADRs associated with it. The study also focuses on ADRs associated with anticoagulants and its management.Methodology: It is a prospective and observational study. It is carried out in a sample size of 120 patients from the month of November 2020- February 2021, in a tertiary care hospital. Results: IV form of anti coagulant is accounted for 85% of prescriptions were as oral anti-coagulants and 15% was found during the study it was observed that administration of anticoagulants were irrespective of INR, APTT, PT, BT, CT and we have observed that 27 patients accountant with bleeding complications, thrombocytopenia and anemia were the most common ADR observed in the patients accounted for 48% of the patients. Conclusion:Anticoagulants being a narrow therapeutic index drugs comes up with complications when not administered properly there is a need to emphasize on its dose regimen and duration to improve the mortality and morbidity of the patients where the role of clinical pharmacist place a vital role in TDM of anticoagulants.