Formulation of Nano Gel Boswellic Acid and Its Antibacterial Activities Against Infection-Causing Bacteria in Acne Vulgaris

Dedi Damhuri, Ietje Wientarsih, Agustin Indrawati, Rini Madyastuti Purwono 1

8th WCPSDM.2021. APR.Published Online 18 APR 2021

Abstract : This study aimed to determine the nano gel boswellic acid (NgBA) formula and to test its antibacterial activity in inhibiting the growth of infection-causing bacteria in acne. The NgBA formula was made into three types and tested for its antibacterial activity using the streak plate method against Propionibacterium acnes, Staphylococcus aureus and Staphylococcus epidermidis. All formulas had semi-solid form, typical BA smell, homogeneous, pH 5, with dry power, dispersibility, and viscosity according to good gel criteria. The highest diameter of the zone of inhibition was found in formula 3 (NgBA-F3) with an average of 26.5 ± 0.19 mm in P. acnes, 28.4 ± 0.31 mm in S aureus, and 29.5 ± 0.65 mm in S. epidermidis. The lowest diameter of the zone of inhibition was found in formula 1 (NgBA-F1) with an average of 16.6 ± 0.31 mm in P. acnes, 22.7 ± 0.37 mm in S. aureus, and 24.8 ± 0.33 mm in S. epidermidis. The mean diameter of the inhibition zone of all formulations in all types of bacteria had a greater value than verile acne gel and gel base. Based on the quality test and antibacterial activity, the best formula is NgBA-F3.