A Research on Enhancement of Solubility of Repaglinide by Betacyclodextrin Complexation Technique

Simachal Panda, SreemoyKanti Das 1

8th WCPSDM.2021. APR.Published Online 18 APR 2021

Abstract : Objectives: the objective of this research is to enhance solubility of Biopharmaceutical Classification System (BCS) class II drug repaglinide by complexation with beta cyclodextrin.
Materials and methods: The drug Repaglinide analysed its physicochemical parameters by Ultra violet (UV) spectroscopical method at 237 nm in 0.1N HCl. The drug was optimised its solubility by complexation with beta cyclodextrin by various techniques. Physical mixture and kneading method type. Phase solubility study, micromeritics study was conducted. Fourier Transform Infra-Red (FTIR) graphs were taken and confirmed its complexation.
Result: The rate of dissolution was compared with pure drug, physical mixture and kneading complexed and found best in kneading method, optimised with methanol at 45 degree centigrade with 1:1.5 molecular ratio.
Conclusion: The micromeritic properties were enhanced, compared to the pure drug as well as rate of dissolution.