Synthesis of the Prodrug to Mask Bitter Taste and its Taste Evaluation

Dr. Bandoo C. Chatale 1

8th WCPSDM.2021. APR.Published Online 18 APR 2021

Abstract : Meloxicam (MX), a nonsteroidal anti-inflammatory drug, widely used to treat arthritis, has a very bitter taste. Chemical modification of the bitter functionality was achieved by synthesis of a prodrug, meloxicam pivalate (MXP). Taste improvement was evaluated using single bottle-test rat model. It was found that palatability of MXP solution improved significantly as compared to MX.