Solid Self Emulsifying Drug Delivery System for Enhancement of Oral Bioavailability

Roma Mathew, Dr JoyammaVarkey 1

8th WCPSDM.2021. APR.Published Online 18 APR 2021

Abstract : Oral route has been the major route of drug delivery for the treatment of many diseases. However, oral delivery of drugs has become challenging as 40% of the new drug candidates exhibit high lipophilicity which reduces the aqueous solubility. To overcome these problems various formulation strategies have been adopted, among which Self Emulsifying Drug Delivery System (SEDDS) is a promising technology due to its ease of formulation and evaluation. SEDDS formulation are isotropic mixture of an oil,surfactant, co-surfactant and drug ,that has the ability to form emulsion with water under gentle agitation as in the gastrointestinal tract, which presents the drug in the solubilized form .The small particle size of the droplets provide large interfacial area which promote higher rate and extent of absorption. SEDDS usually, limited to liquid dosage forms, because many excipients used in SEDDS are not solids at room temperature, which produces some disadvantage such as stability problems, incompatibility, drug leakage, precipitation etc. Solid SEDDS is formulated by incorporating liquid Self Emulsifying ingredients into powders by different solidification techniques. It combine the advantages of SEDDS with those of solid dosage form e.g. low production cost, convenience of process control, high stability and better patient compliance.